![]() ( Abnormal menstrual cycles and purple toe were among the lesser-known reactions on the first go-around.)įewer people have reported fevers after the Pfizer booster: 16.4% of participants in the second-dose study reported fever symptoms, compared with 8.7% of those in the booster study. No new side effects or adverse reactions showed up. After getting boosted, 63.7% of study participants experienced fatigue, 48.4% had headaches and 39.1% felt muscle pain. ![]() Indeed, side effects of the boosters are mimicking those of the initial doses, as you can see from the near-identical data that Pfizer submitted to the Food and Drug Administration after its studies: 61.5% of study participants developed fatigue, 54% had headaches and 39.3% dealt with muscle pain after getting Pfizer's second shot. But their immune systems are responding in other ways - albeit more gradually. Those receptors don't work as well in older people, so side effects could be less noticeable in them. One of those ways is by triggering certain receptors on immune cells, and that can result in fatigue, headaches and other common side effects, as observed in a small University of Pennsylvania study. ![]() That's because the vaccine provides protection in a few different ways. Your body's response might not do anything outwardly." "But if you don't, I wouldn't say it's not working. If you do get side effects, "at least you know it's working," says Charlotte Baker, a professor of epidemiology at Virginia Tech. That holds true for the boosters - which is especially good news in light of preliminary data showing that the Pfizer-BioNTech booster appears to work about as well against the omicron variant of the coronavirus as earlier doses did against earlier variants. "That's why you tend to have more strong side effects from that initial vaccine.If you don't have symptoms, "consider yourself lucky," Stanford University infectious disease physician Abraar Karan said in February. "If you were ever to be exposed to the infection again, your body would basically be able to respond quickly and more robustly that second time around," he added. ![]() Vivek Cherian, an internal-medicine physician in Baltimore, told Insider. "If you've already had a COVID-19 infection, you've developed memory cells from that infection," Dr. About 73% of vaccine recipients who'd previously had COVID-19 developed side effects after dose one of Pfizer-BioNTech's or Moderna's shot, compared with 66% of vaccine recipients who'd never gotten infected. People who've had COVID-19 may develop more side effects after dose 1Ī small study from the Icahn School of Medicine at Mount Sinai found that vaccine side effects such as fatigue, headaches, and chills were more common among people with preexisting immunity to the coronavirus than people who'd never been infected. Fevers were also far more common among second-dose recipients than first-dose recipients in both trials. In Moderna's trial, meanwhile, about five times as many participants developed chills after their second dose as did after their first. Roughly twice as many participants in Pfizer's trial developed chills and joint pain after their second dose than after their first. Account icon An icon in the shape of a person's head and shoulders.
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